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                                October 24, 2023

       David P. Hochman
       Chief Executive Officer
       Orchestra BioMed Holdings, Inc.
       150 Union Square Drive
       New Hope, Pennsylvania 18938

                                                        Re: Orchestra BioMed
Holdings, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed October 10,
2023
                                                            File No. 333-274924

       Dear David P. Hochman:

              We have conducted a limited review of your registration statement
and have the
       following comments.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe a comment applies to your
facts and circumstances
       or do not believe an amendment is appropriate, please tell us why in
your response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this letter, we may have additional comments.

       Registration Statement on Form S-1

       Cover Page

   1.                                                   For each of the
securities being registered for resale, disclose the price that the selling
                                                        securityholders paid
for such securities.
   2.                                                   Please disclose the
exercise prices of the warrants compared to the market price of the
                                                        underlying security. We
note that several of the warrants are out the money, please
                                                        disclose the likelihood
that warrant holders will not exercise their warrants on the cover
                                                        page and provide
similar disclosure in the prospectus summary, risk factors, MD&A and
                                                        use of proceeds
section. Furthermore, as applicable, please describe the impact on your
                                                        liquidity and update
the discussion on the ability of your company to fund your operations
                                                        on a prospective basis
with your current cash on hand.
   3.                                                   We note the significant
number of redemptions of your public shares in connection with
                                                        your business
combination and that the shares being registered for resale will constitute a
 David P. Hochman
FirstName  LastNameDavid
                 Holdings,P.Inc.
                             Hochman
Orchestra BioMed
Comapany
October 24,NameOrchestra
            2023         BioMed Holdings, Inc.
October
Page 2 24, 2023 Page 2
FirstName LastName
         considerable percentage of your public float. We also note that most
of the shares being
         registered for resale were purchased by the selling securityholders
for prices considerably
         below the current market price of the common stock. Highlight the
significant negative
         impact sales of shares on this registration statement could have on
the public trading price
         of the common stock.
Risk Factors
Risks Related to Ownership of Our Common Stock
The future sales, or the perception of future sales, of shares by existing
stockholders and future
exercise of registration rights may..., page 52

4.       Please revise this risk factor to further highlight the negative
pressure potential sales of
         shares pursuant to this registration statement could have on the
public trading price of the
         common stock. To illustrate this risk, disclose the purchase price of
the securities being
         registered for resale and the percentage that these shares currently
represent of the total
         number of shares outstanding. Also disclose that even though the
current trading price is
         significantly below the SPAC IPO price, the private investors have an
incentive to sell
         because they will still profit on sales because of the lower price
that they purchased their
         shares than the public investors.
Management's Discussion and Analysis of Financial Condition and Results of
Operations
Overview, page 60

5.       In light of the significant number of redemptions and the unlikelihood
that the company
         will receive significant proceeds from exercises of the warrants
because of the disparity
         between the exercise price of the warrants and the current trading
price of the common
         stock, expand your discussion of capital resources to address any
changes in the
         company   s liquidity position since the business combination. If the
company is likely to
         have to seek additional capital, discuss the effect of this offering
on the company   s ability
         to raise additional capital.
6.       Please expand your discussion here to reflect the fact that this
offering involves the
         potential sale of a substantial portion of shares for resale and
discuss how such sales could
         impact the market price of the company   s common stock.
General

7.       Revise your prospectus to disclose the price that each selling
securityholder paid for the
         securities being registered for resale. Highlight any differences in
the current trading
         price, the prices that the Sponsor and other selling securityholders
acquired their shares
         and warrants, and the price that the public securityholders acquired
their shares and
         warrants. Disclose that while the Sponsor and other selling
securityholders may
         experience a positive rate of return based on the current trading
price, the public
         securityholders may not experience a similar rate of return on the
securities they
         purchased due to differences in the purchase prices and the current
trading price. Please
 David P. Hochman
Orchestra BioMed Holdings, Inc.
October 24, 2023
Page 3
       also disclose the potential profit the selling securityholders will earn
based on the current
       trading price. Lastly, please include appropriate risk factor
disclosure.
8.     You appear to be registering shares issued or issuable to former
equityholders of
       Orchestra BioMed, Inc. To the extent this is the case, these affiliates
are deemed to be
       underwriters and must set a price at which the shares will be sold
pursuant to the
       prospectus. Refer to Securities Act Rule 145(c). Please revise the
prospectus accordingly.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Benjamin Richie at 202-551-7857 or Margaret Schwartz at
202-551-7153
with any other questions.



                                                              Sincerely,

FirstName LastNameDavid P. Hochman                            Division of
Corporation Finance
                                                              Office of
Industrial Applications and
Comapany NameOrchestra BioMed Holdings, Inc.
                                                              Services
October 24, 2023 Page 3
cc:       Yariv Katz
FirstName LastName