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                          May 20, 2024

       David Hochman
       Chief Executive Officer
       Orchestra BioMed Holdings, Inc.
       150 Union Square Drive
       New Hope, PA 18938

                                                        Re: Orchestra BioMed
Holdings, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed May 15, 2024
                                                            File No. 333-279430

       Dear David Hochman:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Benjamin
Richie at 202-551-7857 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Industrial Applications and

                          Services
       cc:                                              Keith Pisani, Esq.