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  <xsd:element id="obio_SummaryofSignificantAccountingPoliciesDetailsTable" xbrli:periodType="duration" abstract="true" name="SummaryofSignificantAccountingPoliciesDetailsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="obio_SummaryofSignificantAccountingPoliciesDetailsLineItems" xbrli:periodType="duration" abstract="true" name="SummaryofSignificantAccountingPoliciesDetailsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_AgreementDomain" xbrli:periodType="duration" abstract="true" name="AgreementDomain" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_SharesConsideration" xbrli:periodType="duration" name="SharesConsideration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_MedtronicAgreementDetailsTable" xbrli:periodType="duration" abstract="true" name="MedtronicAgreementDetailsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="obio_MedtronicAgreementDetailsLineItems" xbrli:periodType="duration" abstract="true" name="MedtronicAgreementDetailsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_EstimatedFutureProductPrice" xbrli:periodType="duration" xbrli:balance="debit" name="EstimatedFutureProductPrice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ReimbursableResearchAndDevelopmentExpense" xbrli:periodType="duration" xbrli:balance="credit" name="ReimbursableResearchAndDevelopmentExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_MarketableSecuritiesandStrategicInvestmentsDetailsTable" xbrli:periodType="duration" abstract="true" name="MarketableSecuritiesandStrategicInvestmentsDetailsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="obio_MarketableSecuritiesandStrategicInvestmentsDetailsLineItems" xbrli:periodType="duration" abstract="true" name="MarketableSecuritiesandStrategicInvestmentsDetailsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_GainLossOnInvestment" xbrli:periodType="duration" xbrli:balance="credit" name="GainLossOnInvestment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingGranted" xbrli:periodType="duration" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingGranted" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_PercentageOfValuationAllowanceOnNetDeferredTaxAssets" xbrli:periodType="duration" name="PercentageOfValuationAllowanceOnNetDeferredTaxAssets" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_TaxCutsAndJobsActResearchAndExperimentalActivitiesDeferredTaxAsset" xbrli:periodType="instant" xbrli:balance="debit" name="TaxCutsAndJobsActResearchAndExperimentalActivitiesDeferredTaxAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_TaxCutsAndJobsActResearchAndExperimentalActivitiesAmortizationPeriod" xbrli:periodType="duration" name="TaxCutsAndJobsActResearchAndExperimentalActivitiesAmortizationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_OperatingLossCarryforwardsLimitationsOnUseUponCumulativeChangeInOwnershipInterestOfSignificantStockholdersPeriod" xbrli:periodType="duration" name="OperatingLossCarryforwardsLimitationsOnUseUponCumulativeChangeInOwnershipInterestOfSignificantStockholdersPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_OperatingLossCarryforwardsLimitationsOnUseUponCumulativeChangeInOwnershipInterestOfSignificantStockholdersMaximumPercentage" xbrli:periodType="duration" name="OperatingLossCarryforwardsLimitationsOnUseUponCumulativeChangeInOwnershipInterestOfSignificantStockholdersMaximumPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_OperatingLossCarryforwardsIndefiniteCarryforwardPeriodPercentageOfTaxableIncomeLimitationOnAnnualBasis" xbrli:periodType="duration" name="OperatingLossCarryforwardsIndefiniteCarryforwardPeriodPercentageOfTaxableIncomeLimitationOnAnnualBasis" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_IncomeTaxDisclosureLineItems" xbrli:periodType="duration" abstract="true" name="IncomeTaxDisclosureLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_LeasesDetailsTable" xbrli:periodType="duration" abstract="true" name="LeasesDetailsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="obio_LeasesDetailsLineItems" xbrli:periodType="duration" abstract="true" name="LeasesDetailsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_OperatingLeaseRightOfUseAssets" xbrli:periodType="instant" xbrli:balance="debit" name="OperatingLeaseRightOfUseAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_IncomeTaxDisclosureTable" xbrli:periodType="duration" abstract="true" name="IncomeTaxDisclosureTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="obio_UnrecognizedTaxBenefitsDecreaseFromOtherReductions" xbrli:periodType="duration" xbrli:balance="debit" name="UnrecognizedTaxBenefitsDecreaseFromOtherReductions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DeferredLeaseLiabilitiesCurrent" xbrli:periodType="instant" xbrli:balance="credit" name="DeferredLeaseLiabilitiesCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DeferredOfferingAndMergerCostsCurrent" xbrli:periodType="instant" xbrli:balance="credit" name="DeferredOfferingAndMergerCostsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_EffectiveIncomeTaxRateReconciliationTrueUpsPercent" xbrli:periodType="duration" name="EffectiveIncomeTaxRateReconciliationTrueUpsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_EffectiveIncomeTaxRateReconciliationResearchAndDevelopmentUncertainTaxPositionsPercent" xbrli:periodType="duration" name="EffectiveIncomeTaxRateReconciliationResearchAndDevelopmentUncertainTaxPositionsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_EffectiveIncomeTaxRateReconciliationPermanentItemsPercent" xbrli:periodType="duration" name="EffectiveIncomeTaxRateReconciliationPermanentItemsPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_IssuanceOfWarrantsRelatedToPreferredStockFinancing" xbrli:periodType="duration" xbrli:balance="credit" name="IssuanceOfWarrantsRelatedToPreferredStockFinancing" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ReclassificationOfWarrantLiabilityUponExercise" xbrli:periodType="duration" xbrli:balance="debit" name="ReclassificationOfWarrantLiabilityUponExercise" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_IssuanceOfWarrantsRelatedToPreferredStockFinancingNumber" xbrli:periodType="duration" name="IssuanceOfWarrantsRelatedToPreferredStockFinancingNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_ReclassificationOfWarrantLiabilityUponExerciseNumber" xbrli:periodType="duration" name="ReclassificationOfWarrantLiabilityUponExerciseNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_AdditionalExpenseOnAmendmentOfExistingWarrants" xbrli:periodType="duration" xbrli:balance="debit" name="AdditionalExpenseOnAmendmentOfExistingWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DeferredTaxLiabilitiesDepreciationAndAmortization" xbrli:periodType="instant" xbrli:balance="credit" name="DeferredTaxLiabilitiesDepreciationAndAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DeferredTaxLiabilitiesRightOfUseAssets" xbrli:periodType="instant" xbrli:balance="credit" name="DeferredTaxLiabilitiesRightOfUseAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DeferredTaxAssetsLeaseLiabilities" xbrli:periodType="instant" xbrli:balance="debit" name="DeferredTaxAssetsLeaseLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ContractWithCustomerLiabilityRevenueReduced" xbrli:periodType="duration" xbrli:balance="debit" name="ContractWithCustomerLiabilityRevenueReduced" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_TwoThousandNineteenLoanAndSecurityAgreementTrancheOneMember" xbrli:periodType="duration" abstract="true" name="TwoThousandNineteenLoanAndSecurityAgreementTrancheOneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_BusinessAcquisitionEquityInterestIssuedOrIssuableNumberOfSharesIssuedPerShare" xbrli:periodType="instant" name="BusinessAcquisitionEquityInterestIssuedOrIssuableNumberOfSharesIssuedPerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="obio_EarnoutFirstMilestone" xbrli:periodType="instant" name="EarnoutFirstMilestone" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_AgreementAxis" xbrli:periodType="duration" abstract="true" name="AgreementAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" />
  <xsd:element id="obio_BusinessCombinationMember" xbrli:periodType="duration" abstract="true" name="BusinessCombinationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_OrchestraCommonStockMember" xbrli:periodType="duration" abstract="true" name="OrchestraCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_FreeHoldSurgicalIncMember" xbrli:periodType="duration" abstract="true" name="FreeHoldSurgicalIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_LegacyOrchestraMember" xbrli:periodType="duration" abstract="true" name="LegacyOrchestraMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_DeferredLeaseLiabilities" xbrli:periodType="instant" xbrli:balance="credit" name="DeferredLeaseLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DeferredRentOnOperatingActivities" xbrli:periodType="duration" xbrli:balance="debit" name="DeferredRentOnOperatingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_LegacyOrchestraWarrantsMember" xbrli:periodType="duration" abstract="true" name="LegacyOrchestraWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_ManufacturingEquipmentMember" xbrli:periodType="duration" abstract="true" name="ManufacturingEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_MedtronicAgreementMember" xbrli:periodType="duration" abstract="true" name="MedtronicAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_PartnershipRevenueMember" xbrli:periodType="duration" abstract="true" name="PartnershipRevenueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_PrivateWarrantsHeldByEmployeesMember" xbrli:periodType="duration" abstract="true" name="PrivateWarrantsHeldByEmployeesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_PrivateWarrantsHeldBySponsorMember" xbrli:periodType="duration" abstract="true" name="PrivateWarrantsHeldBySponsorMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_ResearchAndDevelopmentEquipmentMember" xbrli:periodType="duration" abstract="true" name="ResearchAndDevelopmentEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_PaymentsForPurchaseOfStrategicInvestmetns" xbrli:periodType="duration" xbrli:balance="credit" name="PaymentsForPurchaseOfStrategicInvestmetns" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_SeriesD1PreferredStockMember" xbrli:periodType="duration" abstract="true" name="SeriesD1PreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_PaymentsForPurchaseOfRelatedPartyConvertibleNotes" xbrli:periodType="duration" xbrli:balance="credit" name="PaymentsForPurchaseOfRelatedPartyConvertibleNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_SubsequentEventsDetailsLineItems" xbrli:periodType="duration" abstract="true" name="SubsequentEventsDetailsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_StrategicInvestmentsLessCurrentPortionMember" xbrli:periodType="duration" abstract="true" name="StrategicInvestmentsLessCurrentPortionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_StrategicInvestmentsMotusGIMember" xbrli:periodType="duration" abstract="true" name="StrategicInvestmentsMotusGIMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_TerumoAgreementMember" xbrli:periodType="duration" abstract="true" name="TerumoAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_strategicInvestmentVivasureMember" xbrli:periodType="duration" abstract="true" name="strategicInvestmentVivasureMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_DocumentAndEntityInformationAbstract" xbrli:periodType="duration" abstract="true" name="DocumentAndEntityInformationAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_PropertyPlantAndEquipmentUsefulLivesTableTextBlock" xbrli:periodType="duration" name="PropertyPlantAndEquipmentUsefulLivesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="obio_PropertyPlantAndEquipmentBalancesTableTextBlock" xbrli:periodType="duration" name="PropertyPlantAndEquipmentBalancesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="obio_ForfeitableSharesMember" xbrli:periodType="duration" abstract="true" name="ForfeitableSharesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_EarnoutConsiderationMember" xbrli:periodType="duration" abstract="true" name="EarnoutConsiderationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_VivasureMember" xbrli:periodType="duration" abstract="true" name="VivasureMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_UnsecuredConvertibleRedeemableNoteReceivableContributions" xbrli:periodType="duration" xbrli:balance="debit" name="UnsecuredConvertibleRedeemableNoteReceivableContributions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" xbrli:periodType="instant" xbrli:balance="credit" name="LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CorporateAndGovernmentDebtSecuritiesMember" xbrli:periodType="duration" abstract="true" name="CorporateAndGovernmentDebtSecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_MonthlyLeaseAndRentalExpense" xbrli:periodType="duration" xbrli:balance="debit" name="MonthlyLeaseAndRentalExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifiedToEquity" xbrli:periodType="duration" xbrli:balance="debit" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityReclassifiedToEquity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_RevenueRecognizedToDate" xbrli:periodType="instant" xbrli:balance="credit" name="RevenueRecognizedToDate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_TermOfBillingFromDateOfMilestoneAchievement" xbrli:periodType="duration" name="TermOfBillingFromDateOfMilestoneAchievement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_TermOfRoyaltyPaymentsFromCloseOfEachQuarter" xbrli:periodType="duration" name="TermOfRoyaltyPaymentsFromCloseOfEachQuarter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_TermOfOptionalServicesFromReceiptOfInvoice" xbrli:periodType="duration" name="TermOfOptionalServicesFromReceiptOfInvoice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_TermOfSirolimusERFFromReceiptOfShippingInvoice" xbrli:periodType="duration" name="TermOfSirolimusERFFromReceiptOfShippingInvoice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_CollaborativeArrangementAbstract" xbrli:periodType="duration" abstract="true" name="CollaborativeArrangementAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element id="obio_TerumoMember" xbrli:periodType="duration" abstract="true" name="TerumoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_CollaborativeArrangementUpfrontPayment" xbrli:periodType="duration" xbrli:balance="debit" name="CollaborativeArrangementUpfrontPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementEquityCommitment" xbrli:periodType="duration" xbrli:balance="debit" name="CollaborativeArrangementEquityCommitment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementPaymentForFinancing" xbrli:periodType="duration" xbrli:balance="credit" name="CollaborativeArrangementPaymentForFinancing" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementAdditionalAmountReceivableOnAchievementOfMilestones" xbrli:periodType="instant" xbrli:balance="debit" name="CollaborativeArrangementAdditionalAmountReceivableOnAchievementOfMilestones" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementRoyaltyRateOnFutureSale" xbrli:periodType="duration" name="CollaborativeArrangementRoyaltyRateOnFutureSale" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_CollaborativeArrangementMilestonePaymentAmountTargetAchievementDatesPassed" xbrli:periodType="duration" xbrli:balance="debit" name="CollaborativeArrangementMilestonePaymentAmountTargetAchievementDatesPassed" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementRemainingTimeBasedMilestonesProbableOfNotAchievingBySpecifiedTargetDate" xbrli:periodType="instant" xbrli:balance="debit" name="CollaborativeArrangementRemainingTimeBasedMilestonesProbableOfNotAchievingBySpecifiedTargetDate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementProceedsFromStockPurchaseAndRevenue" xbrli:periodType="duration" xbrli:balance="debit" name="CollaborativeArrangementProceedsFromStockPurchaseAndRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementSharesFairValue" xbrli:periodType="duration" xbrli:balance="credit" name="CollaborativeArrangementSharesFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementTransactionPrice" xbrli:periodType="duration" xbrli:balance="credit" name="CollaborativeArrangementTransactionPrice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementSalesBasedRoyaltiesPercentage" xbrli:periodType="duration" name="CollaborativeArrangementSalesBasedRoyaltiesPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_CollaborativeArrangementCostIncurred" xbrli:periodType="duration" xbrli:balance="debit" name="CollaborativeArrangementCostIncurred" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CollaborativeArrangementEstimatedTotalCostIncreaseDecreasePercentage" xbrli:periodType="duration" name="CollaborativeArrangementEstimatedTotalCostIncreaseDecreasePercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_CollaborativeArrangementChangeInEstimateIncreaseDecreaseInEarningsPerShareBasic" xbrli:periodType="duration" name="CollaborativeArrangementChangeInEstimateIncreaseDecreaseInEarningsPerShareBasic" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="obio_CollaborativeArrangementChangeInEstimateIncreaseDecreaseInEarningsPerShareDiluted" xbrli:periodType="duration" name="CollaborativeArrangementChangeInEstimateIncreaseDecreaseInEarningsPerShareDiluted" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="obio_ScheduleOfNumberOfSharesOfCommonStockAfterBusinessCombinationTableTextBlock" xbrli:periodType="duration" name="ScheduleOfNumberOfSharesOfCommonStockAfterBusinessCombinationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="obio_ScheduleOfReconciliationOfBusinessCombinationToStatementOfChangesInStockholdersEquityTableTextBlock" xbrli:periodType="duration" name="ScheduleOfReconciliationOfBusinessCombinationToStatementOfChangesInStockholdersEquityTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="obio_HealthSciencesAcquisitionsCorporation2Member" xbrli:periodType="duration" abstract="true" name="HealthSciencesAcquisitionsCorporation2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_Hsac2HoldingsLlcMember" xbrli:periodType="duration" abstract="true" name="Hsac2HoldingsLlcMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_InitialMilestoneEventMember" xbrli:periodType="duration" abstract="true" name="InitialMilestoneEventMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_FinalMilestoneEventMember" xbrli:periodType="duration" abstract="true" name="FinalMilestoneEventMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_PrivateWarrantsMember" xbrli:periodType="duration" abstract="true" name="PrivateWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_RtwInvestmentsLpAndCovidienGroupS..r.l.Member" xbrli:periodType="duration" abstract="true" name="RtwInvestmentsLpAndCovidienGroupS..r.l.Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_MedtronicPlcMember" xbrli:periodType="duration" abstract="true" name="MedtronicPlcMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_RtwInvestmentsLpMember" xbrli:periodType="duration" abstract="true" name="RtwInvestmentsLpMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_ForwardPurchaseAgreementMember" xbrli:periodType="duration" abstract="true" name="ForwardPurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_BackstopAgreementMember" xbrli:periodType="duration" abstract="true" name="BackstopAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_SharesAuthorized" xbrli:periodType="instant" name="SharesAuthorized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_SponsorSharesForfeiturePercent" xbrli:periodType="duration" name="SponsorSharesForfeiturePercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_SponsorSharesForfeitureNumber" xbrli:periodType="duration" name="SponsorSharesForfeitureNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_SponsorSharesForfeitureStockPriceTrigger" xbrli:periodType="duration" name="SponsorSharesForfeitureStockPriceTrigger" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" />
  <xsd:element id="obio_SponsorSharesForfeitureThresholdTradingDays" xbrli:periodType="duration" name="SponsorSharesForfeitureThresholdTradingDays" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" />
  <xsd:element id="obio_SponsorSharesForfeitureThresholdConsecutiveTradingDays" xbrli:periodType="duration" name="SponsorSharesForfeitureThresholdConsecutiveTradingDays" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" />
  <xsd:element id="obio_SharesSubjectToLockUpPeriodPrivateShares" xbrli:periodType="duration" name="SharesSubjectToLockUpPeriodPrivateShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_SharesLockUpPeriod" xbrli:periodType="duration" name="SharesLockUpPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_SponsorWarrantsForfeiturePercent" xbrli:periodType="duration" name="SponsorWarrantsForfeiturePercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_SponsorWarrantsForfeitureNumber" xbrli:periodType="duration" name="SponsorWarrantsForfeitureNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_SponsorWarrantsForfeitureConsideration" xbrli:periodType="duration" xbrli:balance="debit" name="SponsorWarrantsForfeitureConsideration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ClassOfWarrantOrRightNumberOfwarrantsIssued" xbrli:periodType="duration" name="ClassOfWarrantOrRightNumberOfwarrantsIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_WarrantsIssuedNumberOfEmployeesAndDirectors" xbrli:periodType="duration" name="WarrantsIssuedNumberOfEmployeesAndDirectors" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" />
  <xsd:element id="obio_BusinessAcquisitionEarnoutConsiderationEquityInterestIssuedOrIssuableNumberOfShares" xbrli:periodType="duration" name="BusinessAcquisitionEarnoutConsiderationEquityInterestIssuedOrIssuableNumberOfShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_PercentOfShareholdersElectedToParticipateInEarnout" xbrli:periodType="duration" name="PercentOfShareholdersElectedToParticipateInEarnout" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_SharesOfferingAggregateAmount" xbrli:periodType="duration" xbrli:balance="credit" name="SharesOfferingAggregateAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ThresholdCashRemainingAtWorkingCapitalAndTrustAccountForShareIssue" xbrli:periodType="instant" xbrli:balance="debit" name="ThresholdCashRemainingAtWorkingCapitalAndTrustAccountForShareIssue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_CommonStockSharesOutstandingAfterRedemption" xbrli:periodType="instant" name="CommonStockSharesOutstandingAfterRedemption" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_StockIssuedToSponsorAndOtherInitialShareholders" xbrli:periodType="duration" name="StockIssuedToSponsorAndOtherInitialShareholders" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_CommonStockSharesOutstandingPriorToMergerConsideration" xbrli:periodType="instant" name="CommonStockSharesOutstandingPriorToMergerConsideration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_StockIssuedDuringPeriodSharesRecapitalization" xbrli:periodType="duration" name="StockIssuedDuringPeriodSharesRecapitalization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_CashAcquiredThroughReverseRecapitalization" xbrli:periodType="duration" xbrli:balance="debit" name="CashAcquiredThroughReverseRecapitalization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ProceedsFromReverseRecapitalizationBeforeTransactionCosts" xbrli:periodType="duration" xbrli:balance="debit" name="ProceedsFromReverseRecapitalizationBeforeTransactionCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ProceedsFromReverseRecapitalizationAfterTransactionCosts" xbrli:periodType="duration" xbrli:balance="debit" name="ProceedsFromReverseRecapitalizationAfterTransactionCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ProceedsFromIssuanceOfStockReverseRecapitalization" xbrli:periodType="duration" xbrli:balance="debit" name="ProceedsFromIssuanceOfStockReverseRecapitalization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_SharesSubjectToLockUpPeriodInsiderShares" xbrli:periodType="duration" name="SharesSubjectToLockUpPeriodInsiderShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_WarrantsAndRightsOutstandingExercisableTerm" xbrli:periodType="duration" name="WarrantsAndRightsOutstandingExercisableTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_CollaborativeArrangementChangeInEstimateIncreaseDecreaseInRevenue" xbrli:periodType="duration" xbrli:balance="credit" name="CollaborativeArrangementChangeInEstimateIncreaseDecreaseInRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_ScheduleOfWarrantsActivityTableTextBlock" xbrli:periodType="duration" name="ScheduleOfWarrantsActivityTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" />
  <xsd:element id="obio_PreferredWarrantsMember" xbrli:periodType="duration" abstract="true" name="PreferredWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_CommonWarrantsMember" xbrli:periodType="duration" abstract="true" name="CommonWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_WarrantsExercisedNumber" xbrli:periodType="duration" name="WarrantsExercisedNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_WarrantsReclassifiedToEquityNumber" xbrli:periodType="duration" name="WarrantsReclassifiedToEquityNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_WarrantsExerciseDuringPeriodValue" xbrli:periodType="duration" xbrli:balance="credit" name="WarrantsExerciseDuringPeriodValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_AdjustmentsToAdditionalPaidInCapitalWarrantReclassifiedToEquity" xbrli:periodType="duration" xbrli:balance="credit" name="AdjustmentsToAdditionalPaidInCapitalWarrantReclassifiedToEquity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_LiabilityClassifiedWarrantsMember" xbrli:periodType="duration" abstract="true" name="LiabilityClassifiedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_LiabilityClassifiedLegacyOrchestraWarrantsMember" xbrli:periodType="duration" abstract="true" name="LiabilityClassifiedLegacyOrchestraWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_EquityClassifiedWarrantsMember" xbrli:periodType="duration" abstract="true" name="EquityClassifiedWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_EquityClassifiedLegacyOrchestraWarrantsMember" xbrli:periodType="duration" abstract="true" name="EquityClassifiedLegacyOrchestraWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_WarrantLiabilityFairValueDisclosure" xbrli:periodType="instant" xbrli:balance="credit" name="WarrantLiabilityFairValueDisclosure" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_TwoThousandTwentyTwoLoanAndSecurityAgreementMember" xbrli:periodType="duration" abstract="true" name="TwoThousandTwentyTwoLoanAndSecurityAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_TwoThousandTwentyTwoLoanAndSecurityAgreementTrancheOneMember" xbrli:periodType="duration" abstract="true" name="TwoThousandTwentyTwoLoanAndSecurityAgreementTrancheOneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_TwoThousandNineteenLoanAndSecurityAgreementMember" xbrli:periodType="duration" abstract="true" name="TwoThousandNineteenLoanAndSecurityAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_FundoneAndtwoWarrantsMember" xbrli:periodType="duration" abstract="true" name="FundoneAndtwoWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_DebtInstrumentConversionOptionNotExercisableTerm" xbrli:periodType="duration" name="DebtInstrumentConversionOptionNotExercisableTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_WarrantsExercisableForSharesOfCommonStock" xbrli:periodType="instant" xbrli:balance="credit" name="WarrantsExercisableForSharesOfCommonStock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_EstimatedFairValueOfWarrants" xbrli:periodType="instant" xbrli:balance="credit" name="EstimatedFairValueOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DebtInstrumentOtherFinancingCost" xbrli:periodType="instant" xbrli:balance="credit" name="DebtInstrumentOtherFinancingCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DebtInstrumentRepaymentOfInterestOnlyTerm" xbrli:periodType="duration" name="DebtInstrumentRepaymentOfInterestOnlyTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element id="obio_DebtInstrumentPercentageOfInitialCommitmentAmount" xbrli:periodType="duration" name="DebtInstrumentPercentageOfInitialCommitmentAmount" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_DebtInstrumentInitialCommitmentAmount" xbrli:periodType="instant" xbrli:balance="credit" name="DebtInstrumentInitialCommitmentAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_PercentageOfWarrantsOnAmountDrawn" xbrli:periodType="duration" name="PercentageOfWarrantsOnAmountDrawn" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_WarrantIssued" xbrli:periodType="duration" xbrli:balance="credit" name="WarrantIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_DebtInstrumentPercentageOfOriginalPrincipalAmount" xbrli:periodType="duration" name="DebtInstrumentPercentageOfOriginalPrincipalAmount" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" />
  <xsd:element id="obio_DebtInstrumentNumberOfTranches" xbrli:periodType="duration" name="DebtInstrumentNumberOfTranches" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" />
  <xsd:element id="obio_TwoThousandTwentyTwoLoanAndSecurityAgreementTrancheTwoMember" xbrli:periodType="duration" abstract="true" name="TwoThousandTwentyTwoLoanAndSecurityAgreementTrancheTwoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_TwoThousandTwentyTwoLoanAndSecurityAgreementTrancheThreeMember" xbrli:periodType="duration" abstract="true" name="TwoThousandTwentyTwoLoanAndSecurityAgreementTrancheThreeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_EquityIncentivePlan2018Member" xbrli:periodType="duration" abstract="true" name="EquityIncentivePlan2018Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_EquityIncentivePlan2023Member" xbrli:periodType="duration" abstract="true" name="EquityIncentivePlan2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_ShareBasedCompensationExpenseConsultingService" xbrli:periodType="duration" xbrli:balance="debit" name="ShareBasedCompensationExpenseConsultingService" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_SubsequentEventsDetailsTable" xbrli:periodType="duration" abstract="true" name="SubsequentEventsDetailsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" />
  <xsd:element id="obio_DebtConversionConvertedInstrumentWarrantsIssued" xbrli:periodType="duration" xbrli:balance="credit" name="DebtConversionConvertedInstrumentWarrantsIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_OrchestraBiomedIncMember" xbrli:periodType="duration" abstract="true" name="OrchestraBiomedIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_EquityIncentivePlan2018And2023Member" xbrli:periodType="duration" abstract="true" name="EquityIncentivePlan2018And2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_ForfeitureOfWarrantsNumber" xbrli:periodType="duration" name="ForfeitureOfWarrantsNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_IssuanceOfWarrantsRelatedToLegacyOrchestraPreferredStockFinancingNumber" xbrli:periodType="duration" name="IssuanceOfWarrantsRelatedToLegacyOrchestraPreferredStockFinancingNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_AmendmentsOfExistingWarrantsNumber" xbrli:periodType="duration" name="AmendmentsOfExistingWarrantsNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_WarrantsOtherNumber" xbrli:periodType="duration" name="WarrantsOtherNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_ForfeitureOfWarrantsValue" xbrli:periodType="duration" xbrli:balance="debit" name="ForfeitureOfWarrantsValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_IssuanceOfWarrantsRelatedToLegacyOrchestraPreferredStockFinancingValue" xbrli:periodType="duration" xbrli:balance="credit" name="IssuanceOfWarrantsRelatedToLegacyOrchestraPreferredStockFinancingValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_AmendmentsOfExistingWarrantsValue" xbrli:periodType="duration" xbrli:balance="credit" name="AmendmentsOfExistingWarrantsValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_WarrantsOtherValue" xbrli:periodType="duration" xbrli:balance="debit" name="WarrantsOtherValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_StockIssuedDuringPeriodValueSettlementOfEarnout" xbrli:periodType="duration" xbrli:balance="credit" name="StockIssuedDuringPeriodValueSettlementOfEarnout" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_StockIssuedDuringPeriodSharesSettlementOfEarnout" xbrli:periodType="duration" name="StockIssuedDuringPeriodSharesSettlementOfEarnout" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_StockIssuedDuringPeriodSharesWarrantsPursuantToDebtFinancing" xbrli:periodType="duration" name="StockIssuedDuringPeriodSharesWarrantsPursuantToDebtFinancing" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_EffectOfMergerAndRecapitalizationShares" xbrli:periodType="duration" name="EffectOfMergerAndRecapitalizationShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_BusinessAcquisitionEarnOutConsiderationEquityInterestsNumberOfSharesIssuedAfterRounding" xbrli:periodType="duration" name="BusinessAcquisitionEarnOutConsiderationEquityInterestsNumberOfSharesIssuedAfterRounding" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_CollaborativeArrangementAmountReceivableOnMilestonesWithSpecifiedAchievementDates" xbrli:periodType="instant" xbrli:balance="debit" name="CollaborativeArrangementAmountReceivableOnMilestonesWithSpecifiedAchievementDates" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_EarnOutSharesFirstMilestoneRoundedOff" xbrli:periodType="instant" name="EarnOutSharesFirstMilestoneRoundedOff" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element id="obio_FairValueAdjustmentsOfWarrants" xbrli:periodType="duration" xbrli:balance="debit" name="FairValueAdjustmentsOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element id="obio_HaemoneticsCorporationMember" xbrli:periodType="duration" abstract="true" name="HaemoneticsCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" />
  <xsd:element id="obio_AdjustmentsToAdditionalPaidInCapitalWarrantIssuedNet" xbrli:periodType="duration" xbrli:balance="credit" name="AdjustmentsToAdditionalPaidInCapitalWarrantIssuedNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="WarrantsIssuedPursuantToPrivatePlacementFinancing" id="obio_WarrantsIssuedPursuantToPrivatePlacementFinancing" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetsFairValueIncludingMoneyMarketFundDisclosure" id="obio_AssetsFairValueIncludingMoneyMarketFundDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtInstrumentCashPaymentDueWithRespectToCertainFees" id="obio_DebtInstrumentCashPaymentDueWithRespectToCertainFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PaymentOfNetInterestPrepaymentFeesAndLegalFees" id="obio_PaymentOfNetInterestPrepaymentFeesAndLegalFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
</xsd:schema>
